Includes bibliographical references and index.

Machine generated contents note: List of ContributorsPrefacePart 1: Introduction1 Concept & Scope of Modern VaccinesNadeem Sheikh PhD, Huw Davies PhD, Clint Schmidt PhDPart 2: Principles of Vaccine Design2 Stra tegies to Stimulate Innate Immunity for Designing Effective Vaccine Adj uvantsHeather L. Wilson PhD, Scott Napper PhD, George K. Mutwiri, Sylvi a van Drunen-Little van den Hurk, Hugh Townsend PhD VIDO, Lorne A. Babi uk PhD, Andrew A. Potter PhD, Volker Gerdts PhD3 Antigen Processing and Presentation by MHC Class I, II and Non-Classical MoleculesAnthony N. Antoniou PhD, Izabela Lenart, David B. Guiliano, Simon J. Powis PhD4 Un derstanding the Mucosal Immune System for Better Mucosal VaccineJanine Bilsborough PhD, Joanne L. Viney PhD5 Immunological Memory: T Cells in HumansMaria Candela Iglesias, Victor Appay PhD, Arnaud Moris,6 Immunolo gical Memory: B CellsFrances Eun-Hyung Lee MD, Iänaki Sanz MD7 Utility of Mouse Models in Vaccine Design and DevelopmentCatherine M. Bosio PhD , Megan McLeod PhD, Philippa Marrack PhD, Ross M. Kedl8 Utility of Non- Human Primate Models for VaccinePreston A. Marx PhD, Alexander F. Voevo dinPart 3: Antigen Discovery (Macro approach vs. Epitope focused)9 Sequ ence Based Computational Approaches to Vaccine Discovery and DesignDarr ick Carter PhD10 High-Throughput Proteomics (Microarrays only)Huw Davie s PhD11 Phage LibrariesAaron K. Sato PhDPart 4: Antigen Engineering12 A ttenuated Microbial VaccinesRichard W. Titball BSc, FRCPath, Helen S. A tkins BSc, PhD13 Virus-Like Particles as Antigen ScaffoldsBryce Chacker ian PhD, John T. Schiller PhD14 Recombinant MVA Vaccines, Optimisation, Pre-clinical and Product DevelopmentYper Hall BSc, Miles Carroll PhD15 Recombinant Adenoviruses for VaccinationNelson Cesar Di Paolo PhD, Dmi try Shayakhmetov PhD, Andre; Lieber MD, PhD16 Recombinant Avipoxviruses Michael A. Skinner PhD, Stephen M. Laidlaw17 Intracellular Facultative Bacterial Vectors For Cancer ImmunotherapyPatrick Guirnalda , Laurence Wood, Matthew Seavy, Yvonne Paterson PhD18 Nucleic Acid VaccinationBrit ta Wahren, Margaret A. Liu MD19 Artificial Antigen-presenting Cells: La rge Multivalent ImmunogensMatthew F. Mescher PhD, Julie M. CurtsingerPa rt 5: Delivery Systems20 Transcutaneous Immunization via Vaccine Patch Delivery SystemRobert C. Seid PhD, Gregory M. Glenn MD21 Needle-free Je t Injection for Vaccine AdministrationBrian R. Sloat, Hoi K. Tran, Zhen grong Cui PhD22 Oral Vaccines: an old need and some new possibilitiesAm it A. Lugade PhD, Kalathil Suresh PhD, Yasmin Thanavala PhD23 Adjuvants : From Serendipity to Rational DiscoveryDerek T. O'Hagan PhD, Andreas W ack PhD24 Immunostimulatory Properties of Biodegradable MicroparticlesF .A. Sharp, E.C. Lavelle25 Co-administration of Costimulatory MoietiesCa rolina Arancibia, Yvette Latchman PhD26 Toll Receptors in Relation to A djuvant EffectsDipshikha Chakravortty PhD, Amit Lahiri PhD, Priyanka Da s PhDPart 6: Regulatory Considerations27 Regulatory Issues (FDA & EMEA) Murrium Ahmad PhD, Victoria Byers, Peter WilsonPart 7: Evaluating Vacci ne Efficacy28 Immune Monitoring Design within the Development Pipeline for an Immunotherapeutic or Preventive VaccineSylvia Janetzki PhD, Pedr o Romero MD, Mario Roederer PhD, Diane L. Bolton PhD, Camilla Jandus29 Clinical Development Strategy: Nuts and BoltsCandida Fratazzi MD, Claud io Carini MD, PhD30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient StratificationRobert C Rees PhD, Stephanie Laver sin, Cliff Murray PhD, Graham Ball PhDPart 8: Implementing Immunization s/Therapies31 Mass Immunization StrategiesDavid L. Heymann MD, DTM&H, B ruce R. Aylward, Rudolf H. Tangermann32 The Role of Mathematical Models in Vaccine Development and Public Health Decision MakingMarie-Claude B oily PhD, Marc Brisson PhD, Benoit Mãasse PhD, Sir Roy M Anderson FRS, FMedSci33 Vaccine SafetyJohn Iskander MD, MPH, Claudia Vellozzi MD, MPH , Jane Gidudu MD, MPH, Robert T. Chen MD, MA.

"This book addresses a profound deficiency in the field of vaccine r esearch and development, namely the lack of a single volume describing the design and construction of vaccine strategies from first principles to implementation. This is an authoritative textbook that details a co mprehensive and systematic approach to the science of vaccinology focus ing on not only basic science, but the many stages required to commerci alize and navigate the regulatory requirements for human application bo th in the United States and Europe. The book has broad appeal to clinic ians, scientific and medical researchers alike, and graduate students"- -Provided by publisher.